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Study of Neuropathogenesis in Myotonic Dystrophy type 1 in Drosophila Model Organism

by Ritu Sarkar

1 cards · Thesis

Masters thesis — National Brain Research Centre (Deemed University), 2025. Full text: https://archive.org/details/sgng.19050-study-of-neuropathogenesis-in-myotonic-dystrophy-type-1-in-drosop

Card #c1404SynthesisThesis

Study of Neuropathogenesis in Myotonic Dystrophy type 1 in Drosophila Model Organism

In a fruit-fly model of myotonic dystrophy type 1, toxic CUG-repeat RNA caused progressive, targeted neurodegeneration — the mushroom body's learning/memory γ lobe fully degenerated by day 25 while neighboring lobes stayed intact, dopaminergic clusters lost about 35% of neurons (matching motor symptoms), and the brain's autophagy cleanup system broke down, pointing to impaired cellular waste clearance as a therapeutic target.

— In our words · Source: Study of Neuropathogenesis in Myotonic Dystrophy type 1 in Drosophila Model Organism (Ritu Sarkar)

[Use when]

When one genetic cause produces many symptoms, the shared mechanism (here, broken cellular cleanup) is where the therapy lives.

[Why it matters]

DM1 was long treated as a muscle disease; this is part of its reframing as a brain disease too — and the autophagy angle generalizes beyond DM1 to Alzheimer's and Parkinson's.

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